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Article

Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2022

Cariou Marie, Picard Léa, Guéguen Laurent, Jacquet Stéphanie, Cimarelli Andrea, Fregoso Oliver I, Molaro Antoine, Navratil Vincent, Etienne Lucie

Abstract excerpt

The coronavirus disease 19 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a coronavirus that spilled over from the bat reservoir. Despite numerous clinical trials and vaccines, the burden remains immense, and the host determinants of SARS-CoV-2 susceptibility and COVID-19 severity remain largely unknown. Signatures of positive selection detected by comparative...

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Identifiers

PMID: 35947637
DOI: 10.1073/pnas.2206610119
PMCID: PMC9436378

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