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Using Alternative Definitions of Controls to Increase Statistical Power in GWAS

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies (GWAS) are underpowered due to small effect sizes of single nucleotide polymorphisms (SNPs) on phenotypes and extreme multiple testing thresholds. The most common approach for increasing statistical power is to increase sample size. We propose an alternative strategy of redefining case-control outcomes into ordinal case-subthreshold-asymptomatic variables...

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Literature Corpus work: cdb84e6a-fdce-50c0-804e-f4be344a4441
DOI: 10.21203/rs.3.rs-3858178/v1

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