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Article

A cautionary note on using secondary phenotypes in neuroimaging genetic studies.

NeuroImage - 1 Nov 2015

Kim Junghi, Pan Wei

Abstract excerpt

Almost all genome-wide association studies (GWASs), including Alzheimer's Disease Neuroimaging Initiative (ADNI), are based on the case-control study design, implying that the resulting case-control data are likely a biased, not random, sample of the target population. Although association analysis of the disease (e.g. Alzheimer's disease in the ADNI) can be conducted using a standard logistic regression by...

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Identifiers

PMID: 26220747
DOI: 10.1016/j.neuroimage.2015.07.058
PMCID: PMC4604049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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