Article
Design of case-controls studies with unscreened controls.
Annals of human genetics - 1 Sept 2005
Moskvina V, Holmans P, Schmidt K M, Craddock N
Abstract excerpt
Traditionally in genetic case-control studies controls have been screened to exclude subjects with a personal history of illness. This control group has the advantage of optimal power to detect loci involved in illness, but requires more work and may incur substantial cost in recruitment. An alternative approach to screening is to use unscreened controls sampled from the general population. Such controls are...
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