Article

Improved detection of evolutionary selection highlights potential bias from different sequencing strategies in complex genomic-regions

2021-09-30

Abstract excerpt

Balancing selection occurs when multiple alleles are kept at elevated frequencies in equilibrium due to opposing evolutionary pressures. A new statistical method was developed to test for selection using efficient Bayesian techniques. Selection signals in three different data sets, generated with variable sequencing technologies, were compared: clinical trios, HLA NGS typed samples, and whole-genome long-read samp...

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Literature Corpus work: cd93419a-3316-58c8-9c19-0eef4151476a
DOI: 10.1101/2021.09.28.462165

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