Article

Transduction catalysis: doxorubicin accelerates and enhances rAAV-mediated gene expression in the cortex of mouse, cat and monkey

2020-06-08

Abstract excerpt

<h4>SUMMARY</h4> Rapid and efficient gene transduction via recombinant adeno-associated viruses (rAAVs) is highly desirable across many basic and clinical research domains. Here we report vector co-infusion with doxorubicin, a clinical anti-cancer drug, markedly enhanced rAAV-mediated gene expression in the cerebral cortex across mammalian species (cat, mouse, and macaque), acting throughout the time-period exami...

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Literature Corpus work: 4e545a04-69ff-5756-b156-924f359f47b6
DOI: 10.1101/2020.06.08.139667

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