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Article

Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome.

Molecular and cellular biology - 1 Jan 2025

Bieluszewska Anna, Wulfridge Phillip, Fang Kuo-Chen, Hong Yan, Sawada Tomoyo, Erwin Jennifer, Song Hongjun, Ming Guo-Li, Sarma Kavitha

Abstract excerpt

Chromatin regulators are frequently mutated in autism spectrum disorders, but in most cases how they cause disease is unclear. Mutations in the activity dependent neuroprotective protein (ADNP) causes ADNP syndrome, which is characterized by intellectual deficiency and developmental delays. To identify mechanisms that contribute to ADNP syndrome, we used induced pluripotent stem cells derived from ADNP syndrome...

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Identifiers

PMID: 39950682
DOI: 10.1080/10985549.2025.2463892
PMCID: PMC12138805

Genes

ADNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome.PMID 39950682Read ↗

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