Article

Mitochondrial DNA is a sensitive surrogate and oxidative stress target in oral cancer cells

2024-05-27

Abstract excerpt

Cellular oxidative stress mediated by intrinsic and/or extrinsic reactive oxygen species (ROS) is associated with disease pathogenesis. Oxidative DNA damage can naturally be substituted by mitochondrial DNA (mtDNA), leading to base lesion/strand break formation, copy number changes, and mutations. In this study, we devised a single test for the sensitive quantification of acute mtDNA damage, repair, and copy numbe...

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Literature Corpus work: ccfa36f6-d5f5-52a2-b553-dcdb74cdad68
DOI: 10.1101/2024.05.23.595508

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