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The YTHDC1-m6A-GADD45B Axis Promotes Chondrogenesis of hPDLSCs via Suppressing Senescence Through p53/p21 Signalling Pathway

2025-11-03

Abstract excerpt

<title>Abstract</title> <p>Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with limited therapeutic options. Stem cell-based tissue engineering, particularly utilizing human periodontal ligament stem cells (hPDLSCs), represents a promising approach for cartilage regeneration. However, we have previously demonstrated that chronic inflammation and hypoxic stress in the TMJOA microenvironmen...

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Literature Corpus work
ccf1f5ef-ef44-596c-b5a5-43752279fe91
DOI
10.21203/rs.3.rs-7858488/v1
Open publication

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The YTHDC1-m6A-GADD45B Axis Promotes Chondrogenesis of hPDLSCs via Suppressing Senescence Through p53/p21 Signalling PathwayDOI 10.21203/rs.3.rs-7858488/v1
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