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A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence

13 Jun 2024

Abstract excerpt

Abstract Osteoarthritis (OA) is a kind of arthritis that impairs movement and causes joint discomfort. Recent research has demonstrated a connection between cellular senescence and the degenerative processes of OA chondrocytes. In yeast and human cells, protein tyrosine phosphatase 1B (PTP1B) knockdown prolongs longevity; however, the function of PTP1B in chondrocyte senescence has not been investigated. The goal...

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PMID: 38947824
DOI: 10.1021/acsomega.3c10313

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