Article

Early innate immune responses in HIV infection

2019-01-01

Abstract excerpt

Human immunodeficiency virus (HIV)-1 has evolved to evade many cellular innate immune pathways and yet is most typically associated with aberrant immune activation. However, most current models have evaluated this during chronic phases of HIV-1 infection and to date, the early innate immune kinetics remain elusive. Here, we evaluate the impact of HIV-1 infection on cell-intrinsic innate immune responses using both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cca3b445-34b8-5a15-9a34-571559a23120
DOI: 10.25560/80049

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early innate immune responses in HIV infectionDOI 10.25560/80049Read

Interferons and HIV Infection: The Good, the Bad, and the UglySemantic proximity Read

Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early InfectionSemantic proximity Read

Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 PathogenesisSemantic proximity Read

Three immunoregulatory signatures define non-productive HIV infection in CD4 <sup>+</sup> T memory stem cellsSemantic proximity Read

Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathwaySemantic proximity Read

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cellsSemantic proximity Read

Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV‐1 pathogenesisSemantic proximity Read

Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8 <sup>+</sup> T-Cell Antiviral Activity and Correlates with Preservation of the CD4 <sup>+</sup> T-Cell CompartmentSemantic proximity Read

TYPE I INTERFERON-DEPENDENT CELLULAR REMODELING DURING ACUTE PULMONARY MHV INFECTIONSemantic proximity Read

CD4 and CD8 T Cell Immune Activation during Chronic HIV Infection: Roles of Homeostasis, HIV, Type I IFN, and IL-7Semantic proximity Read

Differentially Stimulated CD4+T Cells Display Altered Human Immunodeficiency Virus Infection Kinetics: Implications for the Efficacy of Antiviral AgentsSemantic proximity Read

Polymorphims of innate immunity genes influence disease progression in HIV-1 infected childrenSemantic proximity Read