Article

Antiviral innate immunity is diminished in the upper respiratory tract of severe COVID-19 patients

2022-11-13

Abstract excerpt

Understanding early innate immune responses to coronavirus disease 2019 (COVID–19) is crucial to developing targeted therapies to mitigate disease severity. Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection elicits interferon expression leading to transcription of IFN-stimulated genes (ISGs) to control viral replication and spread. SARS-CoV-2 infection also elicits NF-κB signaling which regulate...

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Literature Corpus work: cc946d69-23cb-5ccf-a71e-54a0a427ae32
DOI: 10.1101/2022.11.08.22281846

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