Article

Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy’s neutralizing antibody problem

2023-11-29

Abstract excerpt

Although adeno-associated virus (AAV) has enjoyed enormous success as a delivery modality for gene therapy, it continues to suffer from the high prevalence of preexisting neutralizing antibodies in human populations, limiting who can receive potentially life-saving treatments. In this regard, AAV therapies generally also must be administered as a single dose since neutralizing antibodies develop in patients who re...

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Literature Corpus work: cc88f612-c933-5158-9d48-be53fac185a0
DOI: 10.1101/2023.11.29.569229

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