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Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study

22 Aug 2022

Abstract excerpt

BACKGROUND: A neuroimaging-based biomarker termed the brain age is thought to reflect variability in the brain's ageing process and predict longevity. Using Insight 46, a unique narrow-age birth cohort, we aimed to examine potential drivers and correlates of brain age. METHODS: Participants, born in a single week in 1946 in mainland Britain, have had 24 prospective waves of data collection to date, including MRI...

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PMID: 36102775
DOI: 10.1016/s2666-7568(22)00167-2

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