Article

Read-Consistent Minimum Unique Substrings: A Parameter-Free, Linear-Time Framework for Genomic Sequence Representation

2026-03-03

Abstract excerpt

Fixed-length k-mers have been the standard unit of genomic sequence representation for over two decades. However, they impose a uniform resolution on genomes whose complexity varies across loci. We introduce Minimum Unique Substrings (MUSs), variable-length sequence units defined by the local uniqueness structure of the genome rather than predefined parameters. We first extend MUS theory from single contiguous str...

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Literature Corpus work: cc5edf04-fd97-5232-aa5a-2cfa304fe857
DOI: 10.64898/2026.02.28.708734

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