Article

Navigating the pangenome coordinate system with Shredtools

2026-07-08

Abstract excerpt

Existing notions of pangenome coordinates rely on hard-to-compute multiple sequence alignments. On the other hand, pangenome-wide exact unique matches (multi-MUMs) can be computed efficiently, and represent conserved stretches of columns in the underlying MSA. We introduce Shredtools, which uses multi-MUMs as pangenome waypoints and allows for sophisticated queries in pangenome coordinates. Its primary query is e...

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Literature Corpus work: da8c7c93-1ed0-5218-b52c-13634dba862d
DOI: 10.64898/2026.07.03.736354

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