Article

Quantitative Assessment of Protein Activity in Orphan Tissues and Single Cells Using the metaVIPER Algorithm

2018-01-22

Abstract excerpt

We and others have shown that transition and maintenance of biological states is controlled by master regulator protein, which can be inferred by interrogating tissue-specific regulatory models (interactomes) with transcriptional signatures, using the VIPER algorithm. Yet, some tissues may lack molecular profiles necessary for interactome inference ( orphan tissues ), or, as for single cells isolated from heterog...

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Literature Corpus work: cc56ebbb-eb76-5d0c-99dc-2f1e364ed520
DOI: 10.1101/252072

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