Article

Human metabolites modulate antifungal efficacy and reveal creatinine-mediated antagonism of flucytosine

2026-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Clearing fungal infections can fail, even when the causative pathogen is susceptible to antifungal drugs in vitro. The reasons for this discrepancy often remain unclear. Here, we report that human metabolites affect antifungal drug efficacy. Studying Saccharomyces cerevisiae, we observed that human serum and common growth supplements alter the minimal inhibitory concentrations (MIC) across majo...

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Literature Corpus work: cc531aed-342c-56de-94e9-306f26212562
DOI: 10.64898/2026.06.12.731662

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