Article

Unexpected central-memory CD8+ T cell reduction hampers the antitumor efficacy of mogamulizumab (anti-CC chemokine receptor 4 mAb) treatment

2020-09-15

Abstract excerpt

<title>Abstract</title> <p>Developing Treg cell-targeted therapies is an important aspect in cancer immunotherapy. Here, we investigate anti-CCR4 mAb (mogamulizumab) with solid cancer patients in phase 1b clinical trial based on the predominant detection of CCR4-expressing eTreg cells in tumors. While eTreg cells in peripheral blood were significantly decreased after mogamulizumab administration in all patients,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 069d7aab-e681-5db7-a28e-2fe852e83820
DOI: 10.21203/rs.3.rs-73503/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unexpected central-memory CD8+ T cell reduction hampers the antitumor efficacy of mogamulizumab (anti-CC chemokine receptor 4 mAb) treatmentDOI 10.21203/rs.3.rs-73503/v1Read

CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotypeSemantic proximity Read

Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia.Semantic proximity Read

MOG-specific CAR Tregs: a novel approach to treat multiple sclerosisSemantic proximity Read

Depletion of CCR8+ Treg cells restores CCR7+ dendritic cell function to drive anti-tumor immunitySemantic proximity Read

CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment.Semantic proximity Read

The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma.Semantic proximity Read

FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodiesSemantic proximity Read

Immunohistochemistry for CCR4 C-terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T-cell leukemia/lymphoma.Semantic proximity Read

A CAR-T response prediction model for r/r B-NHL patients based on a T-cell subset nomogramSemantic proximity Read

Peripheral blood-derived, γ9δ2 t cell-enriched cell lines from glioblastoma multiforme patients exert anti-tumoral effects in vitro.Semantic proximity Read

Multicenter preclinical validation of next-generation CAR T cells: a strategy for harmonization, reproducibility, and its feasibility in clinical translationSemantic proximity Read

Human effector T cells derived from central memory cells rather than CD8(+)T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy.Semantic proximity Read