Article

Single-cell RNA sequencing reveals<i>in vivo</i>signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’

2020-12-08

Abstract excerpt

<h4>ABSTRACT</h4> The in vivo phenotypic profile of T cells reactive to severe acute respiratory syndrome (SARS)-CoV-2 antigens remains poorly understood. Conventional methods to detect antigen-reactive T cells require in vitro antigenic re-stimulation or highly individualized peptide-human leukocyte antigen (pHLA) multimers. Here, we used single-cell RNA sequencing to identify and profile SARS-CoV-2-reactive T ce...

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Literature Corpus work: cc1f2943-7464-5a22-a31b-756cb388d9b7
DOI: 10.1101/2020.12.07.20245274

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