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Antigenic determinants of SARS-CoV-2-specific CD4<sup>+</sup> T cell lines reveals M protein-driven dysregulation of interferon signaling

2022-01-21

Abstract excerpt

We generated CD4 + T cell lines (TCLs) reactive to either SARSCoV-2 spike (S) or membrane (M) proteins from unexposed naïve T cells from six healthy donor volunteers to understand in fine detail whether the S and M structural proteins have intrinsic differences in driving antigen-specific CD4 + T cell responses. Having shown that each of the TCLs were antigen-specific and antigen-reactive, single cell mRNA analyse...

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Literature Corpus work
74d39265-9d27-592c-a264-d441303ef385
DOI
10.1101/2022.01.20.22269491
Open publication

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Antigenic determinants of SARS-CoV-2-specific CD4<sup>+</sup> T cell lines reveals M protein-driven dysregulation of interferon signalingDOI 10.1101/2022.01.20.22269491
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