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Article

Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapy

1 Jul 2021

Abstract excerpt

Adoptive cell therapy with virus-specific T cells has been used successfully to treat life-threatening viral infections, supporting application of this approach to coronavirus disease 2019 (COVID-19). We expand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T cells from the peripheral blood of COVID-19-recovered donors and non-exposed controls using different culture conditions. We observe that the...

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PMID: 34270918
DOI: 10.1016/j.celrep.2021.109432

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