Article

Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 <sup>+</sup> T Cells

2020-07-07

Abstract excerpt

The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4+ T cells from 32 COVID-19 patients. In patients with severe disease compared to mild disease, we found increased proportions of cytotoxic follicular helper (T<sub>FH</sub>) cells and cytotoxic T helper c...

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Literature Corpus work: e191ca13-acd5-59a9-ae01-9441efa4a79d
DOI: 10.2139/ssrn.3641939

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