Article

Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike Protein

2025-09-29

Abstract excerpt

The emergence of the Omicron variant marked a major antigenic shift from previous SARS-CoV-2 variants. While the emergence of new variants of concern was associated with loss of protection from infection, protection from serious disease was maintained. What was less clear was whether this protection was associated with expansion, affinity maturation of pre-existing cross-reactive B cells, or de novo generation of...

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Literature Corpus work: cc161b88-a9f5-51e6-88ce-3f265e286c9a
DOI: 10.1101/2025.09.26.678818

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