Article

miR-378d Regulates Polyploidization and Malignant Phenotype of Tumor Cells Through AKT and RhoA

2021-06-16

Abstract excerpt

Studies have shown that stress such as hypoxia, chemotherapy, radiotherapy can lead to polyploidization of tumor cells, which play an important role in tumor heterogeneity and malignant phenotype. Paclitaxel (PTX) treatment promoted polyploid cancer cells (PCCs) formation, and miR-378d is sharply reduced in PCCs of esophageal squamous cell carcinomas (ESCC) cells, but miR-378d participation PCCs formation and the...

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Literature Corpus work: cc10d312-4f2d-5246-a7fc-1156af1f5246
DOI: 10.20944/preprints202106.0443.v1

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