Article

A knowledge graph approach to discovering drug combination therapies across the phenome

2025-05-13

Abstract excerpt

Combining two clinically approved drugs has potential to improve treatment for common disease. But, with many thousands of combinations possible, clinically testing all pairs of drugs, with all common diseases, is not feasible. Here, we propose DRACO, a new machine learning method for discovering therapeutic drug combinations by leveraging knowledge about which health conditions each drug has been tested for. Our...

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Literature Corpus work: cc0b7ec5-cdf8-54d3-93f4-877625f3cdda
DOI: 10.1101/2025.05.13.25327531

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