Article

Intermediate molecular phenotypes to identify genetic markers of anthracycline-induced cardiotoxicity risk

2023-01-06

Abstract excerpt

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex disease whose polygenic component is mainly unidentified. We propose that levels of intermediate molecular phenotypes in the myocardium associated with histopathological damage could explain CDA susceptibility; so that variants of genes encoding these intermediate molecu...

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Literature Corpus work: cbfef36d-cd59-5042-999f-25211ed40caa
DOI: 10.1101/2023.01.05.522844

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