Article

Reconstructing cancer karyotypes from short read data: the half full and half empty glass

2017-06-20

Abstract excerpt

<h4>Background</h4> During cancer progression genomes undergo point mutations as well as larger segmental changes. The latter include, among others, segmental deletions duplications, translocations and inversions. The result is a highly complex, patient-specific cancer karyotype. Using high-throughput technologies of deep sequencing and microarrays it is possible to interrogate a cancer genome and produce chromos...

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Literature Corpus work: cbb4c180-191d-54be-8302-fb6976d79d59
DOI: 10.1101/152447

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