Back to search

Article

Hypomethylation-Mediated Upregulation of PHOX1 Promotes Gastric Cancer Progression through Transcriptional Upregulation of NGFR

2025-05-20

Abstract excerpt

<title>Abstract</title> <p> Gastric cancer (GC) remains a leading cause of global cancer-related mortality with limited therapeutic options, and its molecular mechanisms are incompletely understood. Through integrative analysis of TCGA and GEO datasets, coupled with clinical cohort validation, we identified recurrent overexpression of the transcription factor PHOX1 in GC tissues, which correlated significantly w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cb8eafc4-8f28-506a-930f-2f98824a65cd
DOI
10.21203/rs.3.rs-6571586/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hypomethylation-Mediated Upregulation of PHOX1 Promotes Gastric Cancer Progression through Transcriptional Upregulation of NGFRDOI 10.21203/rs.3.rs-6571586/v1
Influence of Epigenetic Regulators Expression on Gastric Cancer PrognosisSemantic proximity
Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without MetastasisSemantic proximity
LHPP is associated with favorable survival across diverse cancers with tumor suppressor properties in stomach adenocarcinoma: a pan-cancer analysisSemantic proximity
Different Master Regulators Define Proximal and Distal Gastric Cancer: Insights into Prognosis and Opportunities for Targeted TherapySemantic proximity
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.Semantic proximity
Lack of Relationship Between PROX1 Expression and Clinicopathological Parameters and Prognosis in Gastric Cancer Patients: A Meta-analysis and TCGA AnalysisSemantic proximity
DNA Methylation-Mediated Silencing of Regenerating Protein 1 Alpha (REG1A) Affects Gastric Cancer PrognosisSemantic proximity
High expression of HECW1 is associated with the poor prognosis and cancer progression of gastric cancerSemantic proximity
A Novel Tumor Suppressor Gene, TMEM171, Inhibits the Development of Gastric Cancer by Dephosphorylating IKBα and Inactivating the NF-kB Signaling PathwaySemantic proximity
m6A Methylation Mediates LHPP Acetylation as a Tumour Aerobic Glycolysis Suppressor to Improve the Prognosis of Gastric CancerSemantic proximity
PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOSSemantic proximity
MECP2 promotes migration and invasion of gastric cancer cells via modulating the Notch1/c-Myc/mTOR signaling pathways by suppressing FBXW7 transcriptionSemantic proximity
Select a neighboring publication to make it the new centre.