Back to search

Article

MECP2 promotes migration and invasion of gastric cancer cells via modulating the Notch1/c-Myc/mTOR signaling pathways by suppressing FBXW7 transcription

2020-07-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Methyl-CpG-binding protein 2 (MECP2), an epigenetic regulatory factor, promotes the carcinogenesis and progression of a number of cancers. However, its role in the migration and invasion of gastric cancer (GC) as well as the underlying molecular mechanisms remain unclear.<bold>Methods: </bold>Immunohistochemistry (IHC), Western blot, and quantitative real-time P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bd30095b-54cd-5b5c-91a6-475d513864ed
DOI
10.21203/rs.3.rs-48700/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
MECP2 promotes migration and invasion of gastric cancer cells via modulating the Notch1/c-Myc/mTOR signaling pathways by suppressing FBXW7 transcriptionDOI 10.21203/rs.3.rs-48700/v1
YY1-modulated Long Non-coding RNA SNHG12 Predicts and Promotes Gastric Cancer Metastasis via Activating miR-218-5p/YWHAZ-dependent β-catenin: A Bed to Bench ApproachSemantic proximity
Increased IGFBP7 Expression Correlates with Poor Prognosis and Immune Infiltration in Gastric Cancer: An Integrated Bioinformatics AnalysisSemantic proximity
The m6A reader IGF2BP3 Facilitates Gastric Cancer Progression Through Activating EMT via Upregulating MYC mRNA StabilitySemantic proximity
FTO upregulation induced by MYC suppresses tumour progression in Epstein‒Barr virus-associated gastric cancerSemantic proximity
Sex determining region Y-box 12 (SOX12) promotes gastric cancer metastasis by upregulating MMP7 and IGF1Semantic proximity
A Novel Tumor Suppressor Gene, TMEM171, Inhibits the Development of Gastric Cancer by Dephosphorylating IKBα and Inactivating the NF-kB Signaling PathwaySemantic proximity
E2F1 and E2F7 regulate gastric cancer cell proliferation, respectively, through transcriptional activation and transcriptional repression of MYBL2Semantic proximity
The ZEB1/LAYN cascade promotes cancer cell malignant phenotypes and macrophage M2 polarization in gastric cancerSemantic proximity
Identification of mini‐chromosome maintenance 8 as a potential prognostic marker and its effects on proliferation and apoptosis in gastric cancerSemantic proximity
Overexpression of SHCBP1 predicts poor prognosis of gastric cancerSemantic proximity
The Role of LncRNA NEAT1 in Gastric Cancer: Tumor Development and Potential Therapeutic TargetSemantic proximity
Hematopoietic pre‐B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasionSemantic proximity
Select a neighboring publication to make it the new centre.