Article

A Novel Tumor Suppressor Gene, TMEM171, Inhibits the Development of Gastric Cancer by Dephosphorylating IKBα and Inactivating the NF-kB Signaling Pathway

2022-02-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Gastric cancer (GC) is one of the most common malignant tumors with an unsatisfactory prognosis worldwide. Therefore, it is urgently necessary to explore the mechanism underlying the tumorigenesis of GC. <bold>Methods: </bold>In the present study, we identified that TMEM171 was down-regulated in GC tissues, and its expression was closely associated with the prog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58b54cc7-47c3-5107-a3ba-94812d3d7e6e
DOI: 10.21203/rs.3.rs-1361540/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Novel Tumor Suppressor Gene, TMEM171, Inhibits the Development of Gastric Cancer by Dephosphorylating IKBα and Inactivating the NF-kB Signaling PathwayDOI 10.21203/rs.3.rs-1361540/v1Read

Spatial transcriptomic characteristics of gastric cancer in young and the expression and role of TMEM176B in gastric cancer cellsSemantic proximity Read

HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3pSemantic proximity Read

The ZEB1/LAYN cascade promotes cancer cell malignant phenotypes and macrophage M2 polarization in gastric cancerSemantic proximity Read

WAKMAR2, a Prognosis-related Enhancer RNA in Gastric CancerSemantic proximity Read

Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16Semantic proximity Read

HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3Semantic proximity Read

Calcium Binding Protein S100A16 Expedites Proliferation, Invasion and EMT Process in Gastric CancerSemantic proximity Read

Molecular Mechanism of the Canonical Oncogenic lncRNA MALAT1 in Gastric CancerSemantic proximity Read

KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcomeSemantic proximity Read

Transmembrane protein 176B regulates amino acid metabolism through the PI3K-Akt-mTOR signaling pathway and promotes gastric cancer progressionSemantic proximity Read

AKR1B10 inhibits the proliferation and migration of gastric cancer via regulating epithelial-mesenchymal transitionSemantic proximity Read