Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.

doi:10.1200/JCO.2016.68.7798

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2016

Bagrodia Aditya, Lee Byron H, Lee William, Cha Eugene K, Sfakianos John P, Iyer Gopa, Pietzak Eugene J, Gao Sizhi Paul, Zabor Emily C, Ostrovnaya Irina, Kaffenberger Samuel D, Syed Aijazuddin, Arcila Maria E, Chaganti Raju S, Kundra Ritika, Eng Jana, Hreiki Joseph, Vacic Vladimir, Arora Kanika, Oschwald Dayna M, Berger Michael F, Bajorin Dean F, Bains Manjit S, Schultz Nikolaus, Reuter Victor E, Sheinfeld Joel, Bosl George J, Al-Ahmadie Hikmat A, Solit David B, Feldman Darren R

Abstract excerpt

Purpose Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with advanced GCT exhibit cisplatin resistance, which requires intensive salvage treatment, and have a 50% risk of cancer-related death. To identify a genetic basis for cisplatin resistance, we performed whole-exome and targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cisplatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to RAC1 gene

Share to Mutation

Share to Neoplasms, Germ Cell and Embryonal

Share to Proto-Oncogene Proteins c-mdm2

Share to rac1 GTP-Binding Protein

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 27646943
DOI: 10.1200/JCO.2016.68.7798
PMCID: PMC5477828

Genes

MDM2
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.PMID 27646943Read ↗

The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.Semantic proximity Read ↗

Genomic Features for Therapeutic Insights of Chemotherapy-Resistant, Primary Mediastinal Nonseminomatous Germ Cell Tumors and Comparison with Gonadal CounterpartSemantic proximity Read ↗

Primary Mediastinal and Testicular Germ Cell Tumors in Adolescents and Adults: A Comparison of Genomic Alterations and Clinical ImplicationsSemantic proximity Read ↗

Genomic evolution and chemoresistance in germ-cell tumours.Semantic proximity Read ↗

Mediastinal germ cell tumors: many questions and perhaps an answerSemantic proximity Read ↗

Testicular germ cell tumor genomics.Semantic proximity Read ↗

New insights into germ cell tumor genomicsSemantic proximity Read ↗

Extragonadal germ cell tumors: A clinicopathologic study with emphasis on molecular features, clinical outcomes and associated secondary malignancies.Semantic proximity Read ↗

Cisplatin resistance in germ cell tumours: models and mechanismsSemantic proximity Read ↗

Clonal analyses of refractory testicular germ cell tumorsSemantic proximity Read ↗

Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumoursSemantic proximity Read ↗

Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various PerspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.