Article

The PDIM paradox of <i>Mycobacterium tuberculosis</i> : new solutions to a persistent problem

2023-10-16

Abstract excerpt

Phthiocerol dimycocerosate (PDIM) is an essential virulence lipid of Mycobacterium tuberculosis . In vitro culturing rapidly selects for spontaneous mutations that cause PDIM loss leading to virulence attenuation and increased cell wall permeability. We discovered that PDIM loss is due to a metabolic deficiency of methylmalonyl-CoA that impedes the growth of PDIM-producing bacilli. This can be remedied by supple...

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Literature Corpus work: cb6a98d8-eaae-5962-8b5a-e92197c57600
DOI: 10.1101/2023.10.16.562559

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