Article

Probabilistic network modeling identifies RBPJ as a driver of stemness in Merkel cell carcinoma

2026-06-27

Abstract excerpt

Merkel cell carcinoma (MCC) is a poorly differentiated neuroendocrine carcinoma with limited treatment options, primarily immunotherapy, to which only ∼50% of patients respond. Lineage plasticity drives its poorly differentiated phenotype, in turn promoting tumor aggressiveness and treatment resistance. Targeting the mechanisms underlying lineage plasticity could help induce differentiation, reduce proliferation,...

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Literature Corpus work: 8b723a73-2424-5b34-9fe9-183aa0f333ef
DOI: 10.64898/2026.06.26.734761

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