Article

MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution

2021-01-28

Abstract excerpt

Technical challenges remain in the sequencing of RNA viruses due to their high intra-host diversity. This bottleneck is particularly pronounced when interrogating long-range co-evolution given the read-length limitations of next-generation sequencing platforms. This has hampered the direct observation of long-range genetic interactions that code for protein-protein interfaces with relevance in both drug and vaccin...

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Literature Corpus work: cb46d3a5-591d-57a4-bbb3-fbdbfd228f36
DOI: 10.1101/2021.01.27.428469

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