Article
MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution.
Nucleic acids research - 9 Jul 2021
Gallardo Christian M, Wang Shiyi, Montiel-Garcia Daniel J, Little Susan J, Smith Davey M, Routh Andrew L, Torbett Bruce E
Abstract excerpt
Technical challenges remain in the sequencing of RNA viruses due to their high intra-host diversity. This bottleneck is particularly pronounced when interrogating long-range co-evolved genetic interactions given the read-length limitations of next-generation sequencing platforms. This has hampered the direct observation of these genetic interactions that code for protein-protein interfaces with relevance in both...
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