Article

NDRG1 Targets TAF15 to Promote Endothelial Dysfunction and Hypoxia-Induced Pulmonary Hypertension

2021-08-19

Abstract excerpt

<title>Abstract</title> <p>Background: The mechanism underlying vascular remodeling of hypoxia-induced pulmonary hypertension (HPH) is not fully elucidated. We hypothesized that hypoxia promotes expression of N-myc downstream regulated gene-1 (NDRG1) in human pulmonary arterial endothelial cells (HPAECs), which in turn leads to endothelial dysfunction and contributing to HPH. <h4>Methods:</h4> Lung samples were o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb38f919-94b7-5ff7-b64a-37e162f471c3
DOI: 10.21203/rs.3.rs-794105/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NDRG1 Targets TAF15 to Promote Endothelial Dysfunction and Hypoxia-Induced Pulmonary HypertensionDOI 10.21203/rs.3.rs-794105/v1Read

NDRG1 in Cancer: A Suppressor, Promoter, or Both?Semantic proximity Read

&lt;italic&gt;NDRG2&lt;/italic&gt;: a Myc-repressed gene involved in cancer and cell stressSemantic proximity Read

Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cellsSemantic proximity Read

TXNDC5 Governs Extracellular Matrix Homeostasis in Pulmonary HypertensionSemantic proximity Read

Overexpressed lncRNA AC068039.4 contributes to proliferation and cell cycle progression of pulmonary artery smooth muscle cells via sponging miR-26a-5p/TRPC6 in hypoxic pulmonary arterial hypertensionSemantic proximity Read

NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet–Endothelial Cell Interaction in Pulmonary HypertensionSemantic proximity Read

Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancerSemantic proximity Read

EPAS1 (Endothelial PAS Domain Protein 1) Orchestrates Transactivation of Endothelial ICAM1 (Intercellular Adhesion Molecule 1) by Small Nucleolar RNA Host Gene 5 (SNHG5) to Promote Hypoxic Pulmonary HypertensionSemantic proximity Read

Gene expression profiling of common signal transduction pathways affected by rBMSCs/F92A-Cav1 in the lungs of rat with pulmonary arterial hypertension.Semantic proximity Read

Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signalingSemantic proximity Read

VEGF receptor promotes hypoxia-induced hematopoietic progenitor proliferation and differentiationSemantic proximity Read

Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transitionSemantic proximity Read