Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells

Abstract excerpt

<h4>Background: </h4> and Purpose：Hypoxia, as a risk factor for pulmonary hypertension (PH), was an inducing factor for pulmonary artery endothelial cells (PAECs) injury and inflammation. Pyroptosis induced cell death along with the maturation and secretion of the inflammatory mediators. However, the correlation among pyroptosis, PAECs injury and inflammation remain unknown. Here, we explored, in detail, the effec...

Topics

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• Cancer, Hypoxia, and Metabolism
• Hypertension, Pulmonary
• Hypoxia
• Macrophages
• Muscle, Smooth, Vascular
• Myocytes, Smooth Muscle
• Pulmonary Artery
• Pulmonary Hypertension Research and Treatments

Identifiers and source

Literature Corpus work

b94d3e61-b091-5aff-a140-9f9bf33e36fc

DOI

10.22541/au.165641955.53682528/v1