Article
Transposon Insertion Site Sequencing of Providencia stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements.
mSphere - 27 May 2020
Johnson Alexandra O, Forsyth Valerie, Smith Sara N, Learman Brian S, Brauer Aimee L, White Ashley N, Zhao Lili, Wu Weisheng, Mobley Harry L T, Armbruster Chelsie E
Abstract excerpt
Providencia stuartii is a common cause of polymicrobial catheter-associated urinary tract infection (CAUTI), and yet literature describing the molecular mechanisms of its pathogenesis is limited. To identify factors important for colonization during single-species infection and during polymicrobial infection with a common cocolonizer, Proteus mirabilis, we created a saturating library of ∼50,000 transposon...
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