Article

Ontology-Aware Network Propagation Reveals Heterogeneous Semantic Architectures Across 31 Human Cancers

2026-08-26

Abstract excerpt

Cancer-associated alterations perturb molecular systems whose organization is only partially captured by protein–protein interaction topology. We asked whether Gene Ontology (GO)- derived semantic information can improve reconstruction of mutation-defined cancer modules and, critically, whether the magnitude and ontology source of this improvement vary across tumour types. We constructed recurrent non-silent somat...

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Literature Corpus work: caf61b29-08d3-58f5-bdfe-81f8b7863ec0
DOI: 10.20944/preprints202608.1894.v1

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