Article

Recombinant dimeric PDZ protein inhibitors for long-term relief of chronic pain by AAV therapeutics

2023-03-03

Abstract excerpt

<h4>ABSTRACT</h4> The inadequate state of current pain treatments, the chronic nature of particularly neuropathic pain, and the high impact on quality of life render chronic pain conditions relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered by ade...

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Literature Corpus work: cadb1c9e-4f90-5585-9296-733f9b100c43
DOI: 10.1101/2023.03.03.530962

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