Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.

PloS one - 6 Feb 2008

Viengchareun Say, Servel Nathalie, Fève Bruno, Freemark Michael, Lombès Marc, Binart Nadine

Abstract excerpt

BACKGROUND: The lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary development. Their actions are mediated via binding to PRL receptor (PRLR), highly expressed in brown adipose tissue (BAT), yet their impact on adipocyte function and metabolism remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: PRLR knockout (KO) newborn mice were phenotypically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Animals, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Cold Temperature

Share to Gene Expression Regulation

Share to Insulin-Like Growth Factor II

Share to Mice, Knockout

Share to Receptors, Prolactin

Source

Open in PubMed Open full text

Identifiers

PMID: 18253483
DOI: 10.1371/journal.pone.0001535
PMCID: PMC2212135

Genes

PRLR
PRL
JAK2
PGC
UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.PMID 18253483Read ↗

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.Semantic proximity Read ↗

Beta-cell adaptation to metabolic stresses requires prolactin receptor signalingSemantic proximity Read ↗

From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models.Semantic proximity Read ↗

Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis.Semantic proximity Read ↗

Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy.Semantic proximity Read ↗

Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy OutcomeSemantic proximity Read ↗

Early programming of adipose tissue function: a large-animal perspectiveSemantic proximity Read ↗

The role of prolactin and growth hormone in mammary gland development.Semantic proximity Read ↗

Novel Function of Rev-erbα in Promoting Brown AdipogenesisSemantic proximity Read ↗

Prolactin: A Hormone at the Crossroads of NeuroimmunoendocrinologySemantic proximity Read ↗

The prolactin-deficient mouse has an unaltered metabolic phenotype.Semantic proximity Read ↗

Selective disruption of dopamine D2 receptors in pituitary lactotropes increases body weight and adiposity in female mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.