Article

Genomic analysis of patient-derived xenograft models reveals intra-tumor heterogeneity in endometrial cancer and can predict tumor growth inhibition with talazoparib

2021-03-31

Abstract excerpt

<h4>Background</h4> Endometrial cancer (EC) is a major gynecological cancer with increasing incidence. It comprised of four molecular subtypes with differing etiology, prognoses, and response to chemotherapy. In the future, clinical trials testing new single agents or combination therapies will be targeted to the molecular subtype most likely to respond. Pre-clinical models that faithfully represent the molecular...

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Literature Corpus work: d6335818-d17b-5af2-9557-7d16921105e9
DOI: 10.1101/2021.03.30.436914

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