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Article

Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives.

Cancer metastasis reviews - 1 Sept 2016

Ausoni Simonetta, Boscolo-Rizzo Paolo, Singh Bhuvanesh, Da Mosto Maria Cristina, Spinato Giacomo, Tirelli Giancarlo, Spinato Roberto, Azzarello Giuseppe

Abstract excerpt

Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in head and neck squamous cell carcinoma (HNSCC) patients has improved only marginally during the last couple of decades, and optimal therapy has yet to be devised. Genomic complexity and intratumoral genetic heterogeneity may contribute to treatment resistance...

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Share to Carcinoma, Squamous Cell
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Molecular Targeted Therapy

Share to Neoplasm Grading

Share to Protein Kinase Inhibitors

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Microenvironment

Source

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Identifiers

PMID: 27194534
DOI: 10.1007/s10555-016-9625-1
PMCID: PMC5524458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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