Article

Prognostic Role of Androgen Receptor Splice Variant 7 (AR-V7) in the Pathogenesis of Breast Cancer

2024-10-16

Abstract excerpt

<title>Abstract</title> <p>Background: The Androgen Receptor (AR) has emerged as an endocrine therapy target in Breast Cancer, exhibiting up to 80% expression in clinical cases. AR-V7, a constitutively activated splice variant of AR with a truncated ligand-binding domain (LBD), demonstrates ligand-independent transcriptional activity and resistance to nonsteroidal antiandrogens like Bicalutamide or Enzalutamide,...

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Literature Corpus work: ca2b5bad-675c-56ef-9e6f-a01da55ed0ac
DOI: 10.21203/rs.3.rs-4959402/v1

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