Article
Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues.
Hormones & cancer - 1 Apr 2014
Hu Dong Gui, Hickey Theresa E, Irvine Connie, Wijayakumara Dhilushi Dodampege, Lu Lu, Tilley Wayne D, Selth Luke A, Mackenzie Peter I
Abstract excerpt
The androgen receptor (AR) is widely expressed in human tissues and has biological function in many male and female organs. In particular, the AR plays a critical role in the biology and pathology of the prostate gland. AR activity inhibits breast growth and has pleiotropic actions in breast cancer that are subtype-dependent. Expression of AR splice variants (ARVs) and their role in prostate carcinogenesis has...
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