Titin’s role in diastolic heart function across species

Abstract excerpt

<h4>Background</h4> Cardiac diastolic function and blood pressure are physiologically tightly interconnected. While diastolic function is regulated by post-translational modifications of sarcomeric genes, including titin ( TTN ), isolating its genetic determinants from those influencing blood pressure is challenging due to variable in vivo loading conditions. We aimed to genetically map diastolic function to the...

Topics

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• Cardiomyopathy, Dilated
• Case-Control Studies
• Cohort Studies
• Connectin
• Genetic Variation
• Heart
• High-Throughput Nucleotide Sequencing
• Rats

Identifiers and source

Literature Corpus work

c8799c9b-dbaa-53c5-8365-1cc3166cc5a8

DOI

10.1101/2025.07.29.25332316