Article

Identifying hierarchical cell states and gene signatures with deep exponential families for single-cell transcriptomics

2022-10-18

Abstract excerpt

Single-cell gene expression data characterizes the complex heterogeneity of living systems. Tissues are composed of various cells with diverse cell states driven by different sets of genes. Cell states are often related in a hierarchical fashion, for example, in cell differentiation hierarchies. Clustering which respects a hierarchy, therefore, can improve functional interpretation and be leveraged to remove noise...

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Literature Corpus work: cdfbc2d2-4493-5d1c-84b2-9f59292c7a91
DOI: 10.1101/2022.10.15.512383

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