Article

Origin of the mobile di-hydro-pteroate synthase gene determining sulfonamide resistance in clinical isolates

2018-11-19

Abstract excerpt

Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene. Resistance to sulfonamides is widespread in the clinical setting and predominantly mediated by plasmid- and integron-borne sul1-3 genes encoding mutant DHPS enzymes that do not bind sulfonamides. In spite of their clinical importance, the genetic origin...

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Literature Corpus work: b4308972-59b0-5473-88e3-3c80a68ece04
DOI: 10.1101/472472

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