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Article

In vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut.

mSystems - 17 Sept 2024

Jiang Han, Dong Yuzhi, Jiao Xue, Tang Biao, Feng Tao, Li Ping, Fang Jiehong

Abstract excerpt

The widespread sulfonamide resistance genes sul1, sul2, and sul3 in food and gut bacteria have attracted considerable attention. In this study, we assessed the in vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli, using a murine model. High fitness costs were incurred for sul1 and sul3 gene-dependent E. coli strains in vivo. A fitness advantage was found in three of the eight mice after...

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Identifiers

PMID: 39140732
DOI: 10.1128/msystems.00836-24
PMCID: PMC11406977

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